The character models are done very well, from those you'd expect, such as Doctor Octavius and Mary Jane, to other characters that weren't in the Spider-Man 2 movie - Felicia Harding has never looked so good! The interface is pretty slick and includes a neat 3D overhead 'Spidey-eye' view of New York, which, by the way, you are free to explore and websling throughout.
The sound effects and music are pretty good, helping to reinforce the game without standing out too much. The large amount of voice acting needed for Spider-Man's voice is actually provided by Tobey Maguire, just like in the movies; the game's narration is handled by none other than Bruce Campbell. Don't skip past the tutorial stuff, Campbell's fun to listen to. The only aggravating part of the vocals are the 'bit part' vocals, particularly the people who work at hospitals - often they'll say "You got him here just in time," when you drop off a girl, for example.