Druuna has several different aspects of play, but unfortunately the only enjoyable part of the game is watching the movie sequences! The premise of the story, which is derived from a graphic novel by Paolo Eleuteri Serpieri, is that
Druuna is condemned to a permanent comatose state. In order to begin adventuring, you are required to first connect to her cerebral cortex. Once connected to
Druuna's cerebral cortex, you use the arrow keys to navigate through her mind. This is a sort of psychedelic journey through the mind, with wild colors and cavernous expanses. Once you've given the initial key press, though, the rest is automatic.
Once you've navigated to an adventure segment of the game, you are usually greeted with a FMV sequence. This introduces the scene, and once completed, allows you to navigate Druuna. The up and down arrow keys move her forwards and backwards, and the left and right arrow keys turn her around. As you come across items of interest, a line of text displays at the bottom of the screen indicating what the item is. You can interact with it, as well as open doors and move the character.
Besides either watching the full motion video sequences, using the arrow keys to navigate her mind, or using the arrow and other keys to navigate Druuna through the adventure, you can check the status of Druuna's mind, save or load games, or attempt to normalize her mind. You can collect objects during the adventure portions of the game, but the game automatically combines or uses them, so there's really not much to that aspect of the game.