By the time Batman: The Telltale Series: Episode 4 - Guardian of Gotham starts up, secrets concerning the origin of the Wayne fortune have been revealed to all of Gotham; Bruce, himself, has been removed as CEO of Wayne Enterprises; and the new terrorist group, the Children of Arkham, have not only made Batman's efforts to keep Gotham safe hard to manage, but it seems the drug they are trying to spread across the city has caused newly minted Mayor Dent to become very distrustful, even towards his old friend, Bruce.
Episode 3 - New World Order ends with Bruce being poisoned by the same drug that has affected Harvey and then being forced to attack Oswald Cobblepot, the new CEO of Wayne Enterprises. Unfortunately, Bruce finds himself in a pretty bleak situation when Guardian of Gotham opens up - a padded cell in Arkham Asylum.