While
PixelSkin is very user-friendly and simply designed, there are a few drawbacks. The first of these is somewhat of a mixed bag. The thickness of the skin, which is what helps provide a decent amount of protection, also causes a couple of problems. Where some skins have a hole over all buttons,
PixelSkin covers both the volume and lock buttons. Due to the thickness, the responsiveness of these buttons is somewhat compromised, especially if the skin has slipped slightly. On a related note, I also found that it was sometimes difficult to get a headphone connector fully into the iPhone's jack without pushing and wiggling it around a bit.
Another issue was the initial feel of the case. I found the overall feel to be somewhat slick and not as gripping as I would have liked. This may be something that will fade with use, but it was a bit of a turn-off to an otherwise good item.
The last issue is more theoretical in nature. In my experience, most items made of rubber similar to the PixelSkin tend to grow dirty and dingy over time, especially when being handled constantly. They also resist cleaning. With a list price around $25, these are not "throw-away" cases to most people in my circle of friends, so again, while I did not experience this during my time reviewing the skin, it is something to think about in the long-term.