In
Dead Head Fred, you play Fred. As a recently deceased private investigator, you find yourself awakened in a grungy laboratory at the hands of a strange doctor. It turns out, in your life you were hired to investigate the comings and goings and actions of the owner of the local nuclear plant.
It seems that the pollution from this plant is causing quite a bit of disruption in the environment. Not only are most of the inhabitants of this town badly deformed (like Lefty, a man with a large left arm and leg, but hardly a right arm or leg to speak of... he uses his tommy gun as a crutch), but it is also filled with zombies and various malformed animals.
So, when Fred is discovered by his mark, he ends up dead and dumped near the local sludge-pit. His body is recovered by the aforementioned doctor and revived, well, with all but his head (that is currently a trophy). So now Fred, with his new head, will go on a new quest, this time, to get revenge and his old head back.
Most of the game's enemies consist of zombies of various types. The various enemies have different types of attacks, as well weaknesses and strengths. For the most part, Fred has only his fists to use to defend himself. But Fred can also use his head, literally. Swapping heads with previously defeated types of enemies gains abilities like shooting water or delivering more powerful hits. This is a great mechanic that really adds to Dead Head Fred's depth.