The visuals are a pretty close match to the console versions. Nearly all of the characters from the series are around, as well as one or two new faces. All have multiple costumes and feature smooth, complete animations during gameplay. There are also an impressive number of fairly detailed stages, including a Subway, Float and Rooftop. Of course, you probably won't notice them, but it's good to know that something is happening on the other screen.
Audio is about as good as you could expect from the DS's sound chip. It isn't high-fidelity, 5.1 Surround Sound, but it's a little above low-fidelity mono. After all, you can't butcher a goat and expect prime rib. While things sound good, the song list is borderline at best. There are a few good ones, I especially liked "Breed" (Nirvana), "China Grove" (The Doobie Brothers) and "What I Want" (Daughtry), though a majority of the pop-heavy songs just don't work. "All the Small Things" (Blink 182) and "Spiderwebs" (No Doubt) would be great for something like Rock Band or Guitar Hero World Tour, but not for Guitar Hero. Also, I'd like to request that "All-Star" (or, if possible, Smash Mouth) be permanently banned from everything. I can, however, see some songs being picked because they fit some of the gameplay mechanics a little better, so there's room for a little slack.
Most of the songs are master recordings and the drop in quality doesn't really seem to hurt any of the songs. They're all audible and sound good - especially when using headphones. The only song that really seems to have suffered any sort of degradation in quality is KISS's "Rock and Roll All Night".