Part of the game's distinctness is it's feel. Instead of going for ultra-realistic, the graphics take on a characticture feel as everything looks exaggerated and stereotypical. You play as Bruce, a 50's greaser who finds himself in the middle of the Zombie Apocalypse. From Bruce's slicked-back black hair, to his leather jacket and pistol, you can easily picture our hero being a member of the T-Birds and dating a Pink Lady, especially since his girlfriend, Daisy, sits in a car that would fit nicely in the musical Grease.
The zombies are also interesting to look at, and were made to be a bit of comedic relief as well. The standard guys aren't all that interesting to look at, but as the screen fills up, you will encounter baddies that will charge at you (they have football helmets on), dance towards you (in pink tutus and leotards) or approach you and blow themselves up (they have helmets with flashing lights on their heads). There's quite a variety of zombie classes, and while the creatures within the class all look the same, they are all still enjoyable to see... when you aren't running away from them, of course.
Sound in Burn Zombie Burn! is amusing and gets the job done, but isn't really necessary. Bruce doesn't really talk all that much, and the zombies pretty much just groan in unison. Outside of that, there are the sound effects of the different weapons and the background music. While the various guns tend to sound the same, the music seems to really work well with the game since it tends to get the heart racing and maintains the high tension necessary with any game that has you facing off against unknown numbers of reanimated corpses.