Guacamelee! has the same aesthetic sensibilities as the Tales from Space games. Solid colors may give the game a simple look, but the colors are vibrant and beautiful, especially on the Vita's OLED screen. Juan's lucha libre alter ego is larger than life, much like those of real luchadores. All of his moves suggest wrestling; simple melee blows look like they should, but the handful of grappling abilities really goes a long way in selling the theme of the game. Like in Tales from Space, there are a lot of nerd culture references. I won't spoil any of them, but I'll just say that the developers at DrinkBox obviously love what they do, and are not afraid to express it. One of my favorite visual touches lies in the sequence that follows the acquisition of each new ability. Juan assumes a pose with the goat man while a seizure-inducing display of garish neon backgrounds and text flickers wildly.
Sound-wise, Guacamelee! is pure Mexico. Mariachi goofiness pervades the entire game, but when the horns aren't bleating, the guitars are strumming. Switching between the Land of the Dead and the Land of the Living always results in some subtle musical difference; the same song will be playing, but under a different arrangement. All of the thwacks, bumps, and other general comic book onomatopoeia accompanies each landed hit and bodyslam (sans actual words, of course), which is appropriate for this mostly family-friendly game.